Year: 2010
Type: dissertation
Study design: Observational Study
Abstract: __Abstract_ \n \n__Introduction__: Treatment options for Staphylococcus aureus infections are becoming \nincreasingly limited because of the extensive emergence of antimicrobial resistance \namong S. aureus isolates. Consequently, novel approaches, including vaccines and \nimmunotherapy, are urgently needed. In order to develop such alternative strategies, \na better understanding of the human antibody response to S. aureus exposure, is \nnecessary. \n__Methods__: The qualitative and quantitative levels of antibodies directed to important \nS. aureus cell wall-associated proteins, immune-modulating proteins and toxins were \nmeasured in healthy individuals, children and patients suffering from diverse S. \naureus infections. A flow cytometry technique based on differentially coloured \nmicrospheres was used (xMAP® Technology). \n__Results__: In patients as well as in healthy children and adults, the \nantistaphylococcal antibody profiles showed extensive inter-individual variability. \nWhen groups were compared and significant differences were found, the level of \nantistaphylococcal antibodies was hig
Author: Nelianne J. Verkaik
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2109550718