Work

Mechanisms of Autophagy

Year: 2015

Type: review

Abstract: The formation of the autophagosome, a landmark event in autophagy, is accomplished by the concerted actions of Atg proteins. The initial step of starvation-induced autophagy in yeast is the assembly of the Atg1 complex, which, with the help of other Atg groups, recruits Atg conjugation systems and initiates the formation of the autophagosome. In this review, we describe from a structural-biological point of view the structure, interaction, and molecular roles of Atg proteins, especially those in the Atg1 complex and in the Atg conjugation systems.

Source: Annual Review of Biophysics

DOI: 10.1146/annurev-biophys-060414-034248

Authors: Nobuo N. Noda, Fuyuhiko Inagaki

Institutions: Japan Science and Technology Agency, Microbial Chemistry Research Foundation, Hokkaido University

Language: English

Topic: Autophagy in Disease and Therapy

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

Funders: Ministry of Education, Culture, Sports, Science and Technology, Japan Society for the Promotion of Science

Awards: G4860794242, G7615071395