Predicting Adult-Onset Autoimmune Diabetes
Year: 2010
Type: article
Abstract: “What is time?” asked Saint Augustine in his Confessions , “When someone asks me, I know. But as soon as someone comes to question me on this matter, and I try to explain, I don't know anymore.” A physician asked to define an autoimmune disease has a similar sense of frustration. For the perplexed, three features of autoimmune diseases, derived from Witebsky's postulates, might help: 1 ) the presence of defined autoantigens and autoantibodies; 2 ) passive transfer of T-lymphocytes, which leads to disease development; and 3 ) successful immunomodulation of disease (1). Indeed, for type 1 diabetes in humans we know that autoantibodies are common and, alas, also that the second postulate is unethical and the third controversial. In reality, a disease is considered autoimmune when target organ destruction is allied to the presence of disease-specific target organ autoantibodies (2). It is through their clinical phenotype that diseases gain identity; only recently have we used genetic and immune responses to adapt disease names. Therefore, the historical characteristic of severe diabetes as childhood-onset disease was supplanted by insulin-dependent diabetes and with identification of diabetes-associated autoantibodies and genetic susceptibility through the major histocompatibilty complex (MHC) for type 1 diabetes, or more precisely type 1a diabetes, with type 2 diabetes being everything type 1 diabetes was not (2,3).
From the earliest years it was …
Source: Diabetes
DOI: 10.2337/db09-1620
Author: R. David Leslie
Institution: Blizard Institute
Language: Finnish
Subfield: Genetics
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W2109661346