Enhancement of Major Histocompatibility Class I Protein Synthesis by DNA Damage in Cultured Human Fibroblasts and Keratinocytes
Year: 1989
Type: article
Abstract: Exposure of primary human fibroblasts or simian virus 40-transformed human keratinocytes to several different classes of DNA damage, including UV light C (254 nm), resulted in a rapid increase in the expression of human major histocompatibility class I (MHC-I) proteins. MHC-I induction was also detected after exposure to low doses of the protein synthesis inhibitor cycloheximide, suggesting that MHC-I induction by DNA damage may be a component in a derepressible cellular SOS pathway.
Source: Molecular and Cellular Biology
DOI: 10.1128/mcb.9.2.847
Authors: M E Lambert, Z A Ronai, I B Weinstein, J I Garrels
Institution: Cold Spring Harbor Laboratory
Language: English
Topic: DNA Repair Mechanisms
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2109780850