Work

Radioprotectors and Mitigators of Radiation-Induced Normal Tissue Injury

Year: 2010

Type: article

Abstract: Radiation is used in the treatment of a broad range of malignancies. Exposure of normal tissue to radiation may result in both acute and chronic toxicities that can result in an inability to deliver the intended therapy, a range of symptoms, and a decrease in quality of life. Radioprotectors are compounds that are designed to reduce the damage in normal tissues caused by radiation. These compounds are often antioxidants and must be present before or at the time of radiation for effectiveness. Other agents, termed mitigators, may be used to minimize toxicity even after radiation has been delivered. Herein, we review agents in clinical use or in development as radioprotectors and mitigators of radiation-induced normal tissue injury. Few agents are approved for clinical use, but many new compounds show promising results in preclinical testing.

Source: The Oncologist

DOI: 10.1634/theoncologist.2009-s104

Authors: Deborah Citrin, Ana P. Cotrim, Fuminori Hyodo, Bruce J. Baum, Murali C. Krishna, James B. Mitchell

Institutions: National Cancer Institute, National Institutes of Health, National Institute of Dental and Craniofacial Research, Center for Cancer Research

Language: English

Topic: Effects of Radiation Exposure

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Cancer Institute, National Institute of Dental and Craniofacial Research, NHLBI Division of Intramural Research