Intestinal Bacteria and the Regulation of Immune Cell Homeostasis
Year: 2010
Type: review
Abstract: The human intestine is colonized by an estimated 100 trillion bacteria. Some of these bacteria are essential for normal physiology, whereas others have been implicated in the pathogenesis of multiple inflammatory diseases including IBD and asthma. This review examines the influence of signals from intestinal bacteria on the homeostasis of the mammalian immune system in the context of health and disease. We review the bacterial composition of the mammalian intestine, known bacterial-derived immunoregulatory molecules, and the mammalian innate immune receptors that recognize them. We discuss the influence of bacterial-derived signals on immune cell function and the mechanisms by which these signals modulate the development and progression of inflammatory disease. We conclude with an examination of successes and future challenges in using bacterial communities or their products in the prevention or treatment of human disease.
Source: Annual Review of Immunology
Authors: David A. Hill, David Artis
Institution: University of Pennsylvania
Language: English
Topic: Gut microbiota and health
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
Awards: Agents of International Health & Bioterrorism Concern, G1825519441, Immunobiology of Normal and Neoplastic Lymphocytes, Functional biology of Il-25, Parasitology: Modern approaches, Innate immunity and inflammation following helminth infection, G686481798, Microbial Pathogenesis and Genomics, Role of the Intestinal Epithelium in Immunity, Purchase of the Roche GS SLX Sequencing System, Immuno-regulation of GI nematode infection
OpenAlex ID: W2109843135