Work

Current tools for the identification of miRNA genes and their targets

Year: 2009

Type: review

Abstract: The discovery of microRNAs (miRNAs), almost 10 years ago, changed dramatically our perspective on eukaryotic gene expression regulation. However, the broad and important functions of these regulators are only now becoming apparent. The expansion of our catalogue of miRNA genes and the identification of the genes they regulate owe much to the development of sophisticated computational tools that have helped either to focus or interpret experimental assays. In this article, we review the methods for miRNA gene finding and target identification that have been proposed in the last few years. We identify some problems that current approaches have not yet been able to overcome and we offer some perspectives on the next generation of computational methods.

Source: Nucleic Acids Research

DOI: 10.1093/nar/gkp145

Authors: N. D. Mendes, A. T. Freitas, M.-F. Sagot

Institutions: Lyon 1 Université, Centre National de la Recherche Scientifique, Laboratoire de Biométrie et Biologie Evolutive, Instituto de Engenharia de Sistemas e Computadores Investigação e Desenvolvimento, Institut national de recherche en sciences et technologies du numérique

Language: English

Topic: MicroRNA in disease regulation

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $3,992

Funders: Institut national de recherche en informatique et en automatique (INRIA), Agence Nationale de la Recherche, Fundação para a Ciência e a Tecnologia