Work

Erythropoetin receptor expression in the human diabetic retina

Year: 2009

Type: article

Abstract: BACKGROUND: Recent evidence suggests erythropoietin (EPO) and the erythropoietin receptor (EPOR) may play a direct role in the pathogenesis of diabetic retinopathy. Better characterization of the EPO-EPOR signaling system in the ischemic retina may offer a new therapeutic modality for ischemic ophthalmic diseases. This study was performed to identify EPOR mRNA expression in the human diabetic eye. FINDINGS: EPOR antisense RNA probes were validated on human pancreas tissue. In the normal eye, EPOR was expressed in the retinal ganglion cell layer. Minimal expression was observed in the inner and outer nuclear layer. Under conditions of diabetic retinopathy, EPOR expression shifted to photoreceptor cells. Increased expression was also observed in the peripheral retina. CONCLUSION: EPOR expression may be a biomarker or contribute to disease mechanisms in diabetic retinopathy.

Source: BMC Research Notes

DOI: 10.1186/1756-0500-2-234

Authors: Shaival S Shah, Stephen H Tsang, Vinit B Mahajan

Institutions: University of Iowa, University of Iowa Hospitals and Clinics, Columbia University Irving Medical Center, Columbia University

Language: English

Topic: Erythropoietin and Anemia Treatment

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,690