Year: 2014
Type: article
Abstract: Diabetic nephropathy is a major cause of end-stage renal disease throughout the world. Elevated oxidative stress in diabetic patients results from overproduction of reactive oxygen species and decreased efficiency of antioxidant defenses. Moreover, diabetes-associated metabolic disorders impair activities of enzymes of the mitochondrial respiratory chain complex. Therefore, oxidative stress is closely related to mitochondrial dysfunction. This paper reviews studies of mitochondrial dysfunction in diabetic nephropathy.
Authors: Farhad Khoshjou, Farahnaz Dadras
Institution: Hamedan University of Medical Sciences
Language: English
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W2110317166