Work

Multifocal interferometric synthetic aperture microscopy

Year: 2014

Type: article

Abstract: There is an inherent trade-off between transverse resolution and depth of field (DOF) in optical coherence tomography (OCT) which becomes a limiting factor for certain applications. Multifocal OCT and interferometric synthetic aperture microscopy (ISAM) each provide a distinct solution to the trade-off through modification to the experiment or via post-processing, respectively. In this paper, we have solved the inverse problem of multifocal OCT and present a general algorithm for combining multiple ISAM datasets. Multifocal ISAM (MISAM) uses a regularized combination of the resampled datasets to bring advantages of both multifocal OCT and ISAM to achieve optimal transverse resolution, extended effective DOF and improved signal-to-noise ratio. We present theory, simulation and experimental results.

Source: Optics Express

DOI: 10.1364/oe.22.016606

Authors: Yang Xu, Xiong Kai Benjamin Chng, Steven G. Adie, Stephen A. Boppart, P. Scott Carney

Institutions: University of Illinois Urbana-Champaign, Cornell University

Language: English

Topic: Optical Coherence Tomography Applications

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $2,270

Funders: National Institutes of Health, National Institute of Biomedical Imaging and Bioengineering