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Inside Cover: Disruption of Transcriptionally Active Stat3 Dimers with Non‐phosphorylated, Salicylic Acid‐Based Small Molecules: Potent in vitro and Tumor Cell Activities (ChemBioChem 12/2009)

Year: 2009

Type: article

Abstract: The inside cover picture shows the culmination of a rational drug discovery program of Stat3 inhibitors. Computational modeling of the most potent salicylic acid-based therapeutic shows excellent occupation of the Stat3-SH2 domain, thereby inhibiting its homodimerization. For details, see the communication by P. T. Gunning et al. on p. 1959 ff.

Source: ChemBioChem

DOI: 10.1002/cbic.200990048

Authors: Steven Fletcher, Jardeephi Singh, Xiaolei Zhang, Peibin Yue, Brent D. G. Page, Sumaiya Sharmeen, Vijay M. Shahani, Wei Zhao, Aaron D. Schimmer, James Turkson, Patrick T. Gunning

Institutions: University of Toronto, University of Central Florida, Princess Margaret Cancer Centre

Language: English

Topic: Cytokine Signaling Pathways and Interactions

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

Open Access status: bronze

OpenAlex ID: W2110337055

FWCI:

Cites:

Cited by: 1

Related to: 10