Work

Azole Cross-Resistance in Aspergillus fumigatus

Year: 2002

Type: article

Abstract: We susceptibility tested 17 clinical isolates of Aspergillus fumigatus, for most of which MICs of itraconazole were elevated (MIC at which 50% of the isolates tested are inhibited, 16 microg/ml), against itraconazole, posaconazole, ravuconazole, and voriconazole. Posaconazole was the most active against itraconazole-susceptible isolates. A complex pattern of cross-resistance and hypersusceptibility was seen with voriconazole and ravuconazole, suggesting marked differences in activity and mechanisms of resistance.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.46.2.556-557.2002

Authors: J. Mosquera, D. W. Denning

Institutions: University of Manchester, Wythenshawe Hospital

Language: English

Topic: Antifungal resistance and susceptibility

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2110508114

FWCI: 9.722

Cites: 12

Cited by: 121

Related to: 10