Work

Acyclic N-halamine-immobilized polyurethane: Preparation and antimicrobial and biofilm-controlling functions

Year: 2015

Type: article

Abstract: Hydroxyl groups were introduced onto polyurethane surfaces through 1,6-hexamethylene diisocyanate activation, followed by diethanolamine hydroxylation. Polymethacrylamide was covalently attached to the hydroxylated polyurethane through surface grafting polymerization of methacrylamide using cerium (IV) ammonium nitrate as an initiator. After bleach treatment, the amide groups of the covalently bound polymethacrylamide chains were transformed into N-halamines. The new N-halamine-immobilized polyurethane provided a total sacrifice of 10 7 −10 8 colony forming units per milliliter of Staphylococcus aureus (Gram-positive bacteria), Escherichia coli (Gram-negative bacteria), and Candida albicans (fungi) within 10 min and successfully prevented bacterial and fungal biofilm formation. The antimicrobial and biofilm-controlling effects were both durable and rechargeable, pointing to great potentials of the new acyclic N-halamine-immobilized polyurethane for a broad range of related applications.

Source: Journal of Bioactive and Compatible Polymers

DOI: 10.1177/0883911515569007

Authors: Jie Luo, Nuala Porteous, Jiajin Lin, Yuyu Sun

Institutions: University of Massachusetts Lowell, The University of Texas at San Antonio Health Science Center

Language: English

Topic: Antimicrobial agents and applications

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funder: National Institute of Dental and Craniofacial Research

Award: Rechargeable Antimicrobial Dental Unit Waterline Tubing