Pathophysiology & genetics of obstructive sleep apnoea.
Year: 2010
Type: review
Abstract: Obstructive sleep apnoea (OSA) is a highly prevalent condition with proven neurocognitive and cardiovascular consequences. OSA patients experience repetitive narrowing or collapse of the pharyngeal airway during sleep. Multiple factors likely underlie the pathophysiology of this condition with considerable inter-individual variation. Important risk factors for OSA include obesity, male gender, and ageing. However, the mechanisms underlying these major risk factors are not well understood. We briefly review the state-of-the-art knowledge regarding OSA pathogenesis in adults and highlight the potential role of genetics in influencing key OSA pathophysiological traits.
Source: PubMed
Institutions: Brigham and Women's Hospital, Harvard University
Language: English
Subfield: Physiology (medical)
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: Sleep Apnea and Obesity: Cardiovascular Risk Assessment, Assessment of Upper Airway Mechanics Using Newer EMG Techniques, Mechanisms Underlying the Aging Predisposition to Obstructive Sleep Apnea, Is Neuromyopathy Important in Obstructive Sleep Apnea?, The Genetics of Metabolic Dysfunction in Sleep Apnea, Training in Sleep, Circadian, and Respiratory Neurobiology
OpenAlex ID: W2111274107