Work

Making of Viral Replication Organelles by Remodeling Interior Membranes

Year: 2010

Type: article

Abstract: Positive-stranded RNA (+RNA) viruses exploit host cell machinery by subverting host proteins and membranes and altering cellular pathways during infection. To achieve robust replication, some +RNA viruses, such as poliovirus (PV), build special intracellular compartments, called viral replication organelles. A recent work from the Altan-Bonnett laboratory [1] gave new insights into the formation of poliovirus replication organelles, which are unique subcellular structures containing many individual replication complexes as a result of dynamic cellular membrane remodeling.

Source: Viruses

DOI: 10.3390/v2112436

Authors: Zsuzsanna Sasvari, Peter D. Nagy

Institution: University of Kentucky

Language: English

Topic: Viral Infections and Immunology Research

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

Open Access status: gold

Estimated APC paid: $3,137

Funders: National Institutes of Health, National Institute of Allergy and Infectious Diseases