Racial Differences in Diffusion of Intensity-Modulated Radiation Therapy for Localized Prostate Cancer
Year: 2015
Type: article
Study design: Observational Study
Abstract: Intensity-modulated radiation therapy (IMRT), an innovative treatment option for prostate cancer, has rapidly diffused over the past decade. To inform our understanding of racial disparities in prostate cancer treatment and outcomes, this study compared diffusion of IMRT in African American (AA) and Caucasian American (CA) prostate cancer patients during the early years of IMRT diffusion using the Surveillance, Epidemiology and End Results (SEER)-Medicare linked database. A retrospective cohort of 947 AA and 10,028 CA patients diagnosed with localized prostate cancer from 2002 through 2006, who were treated with either IMRT or non-IMRT as primary treatment within 1 year of diagnoses was constructed. Logistic regression was used to examine potential differences in diffusion of IMRT in AA and CA patients, while adjusting for socioeconomic and clinical covariates. A significantly smaller proportion of AA compared with CA patients received IMRT for localized prostate cancer (45% vs. 53%, p < .0001). Racial differences were apparent in multivariable analysis though did not achieve statistical significance, as time and factors associated with race (socioeconomic, geographic, and tumor related factors) explained the preponderance of variance in use of IMRT. Further research examining improved access to innovative cancer treatment and technologies is essential to reducing racial disparities in cancer care.
Source: American Journal of Men s Health
Language: English
Subfield: Urology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funders: California Department of Public Health, University of Southern California, National Institutes of Health, Centers for Disease Control and Prevention, National Cancer Institute, National Center for Research Resources, National Center for Chronic Disease Prevention and Health Promotion, National Center for Advancing Translational Sciences, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
Awards: G1289825209, G1393855433, G1905122228, G2238803135, Carolina Community Network, G2612351997, G2639781304, G3014186981, Academic Training in Oncology at the University of North Carolina at Chapel Hill, G3123501928, G3149091152, G3161224617, G3190882026, G3509688676, UNC Clinical and Translational Science Award, Carolina Community Network Center to Reduce Cancer Health Disparities (CCN II), Implementing Systemic Interventions to Close the Discovery-Delivery Gap, G4203349661, G4322373146, G4393609197, G4527459645, Statistical Methods for Cancer Clinical Trials, G480705112, G5333917095, G5433357946, Cancer Health Disparities Training Program, G5570217171, G6795547015, G7195422766, G793654858, G8923144227, Biostatistics for Research in Genomics and Cancer
OpenAlex ID: W2111317639