Work

Fat confounds the observed apparent diffusion coefficient in patients with hepatic steatosis

Year: 2012

Type: article

Abstract: PURPOSE: Triglyceride signal contained in peaks near the water peak remains unsuppressed by conventional fat suppression techniques used in diffusion-weighted imaging. In this work, we investigated the dependence of the apparent diffusion coefficient (ADC) on liver fat content and whether it is confounded by fat signal. METHODS: 43 patients underwent liver diffusion-weighted imaging (b = 0, 500 s/mm(2)) and single-voxel MR-spectroscopy. Proton density fat-fraction (PDFF; range 0.23-34.5%) was measured from MR-spectroscopy. A theoretical model was developed to account for the effects of fat on observed ADC, and used to correct the ADC. Linear correlation analysis was performed to assess the relationship between PDFF and ADC before and after correction. RESULTS: Linear correlation analysis showed an inverse dependence between observed ADC and PDFF before correction (r(2) = 0.132; P = 0.017), and no dependence after correction (r(2) = 0.033; P = 0.24). CONCLUSION: The observed decrease in ADC in patients with fatty liver is, at least in part, artifactual due to residual fat signal near the water peak.

Source: Magnetic Resonance in Medicine

DOI: 10.1002/mrm.24535

Authors: Jan Hansmann, Diego Hernando, Scott B. Reeder

Institutions: University of Wisconsin–Madison, Heidelberg University, University Medical Centre Mannheim, Medizinische Fakultät Mannheim

Language: English

Topic: Advanced MRI Techniques and Applications

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Wisconsin Alumni Research Foundation, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Biomedical Imaging and Bioengineering