Control mechanisms of cell proliferation in intestinal epithelium
Year: 1977
Type: dissertation
Abstract: In the adult organism some organs and tissues still\\ncontain proliferating and differentiating cells, whereas\\nother organs only consist of non-dividing specialized\\ncells. On the basis of their proliferative activity cell\\npopulations may be classified into three categories (135,\\n138,208). In some cell populations, e.g. neurons, no cell\\ndivisions occur in the adult organism, and these have been\\nreferred to as "static" or "stable" cell populations. In\\nother cell populations the number of cells keeps increasing\\nin the adult organism at a slow rate with scattered mitoses,\\ne.g. parenchymal cells of liver and kidney; such cell populations\\nare called "growing" or 11 expanding" cell populations.\\nIn some organ systems cell proliferation occurs at a\\nhigh rate in the adult organism, and mitotic figures are\\nabundant. These cell populations do not increase in size,\\nor only to a slight degree, and cell production is balanced\\nby continuous cell loss. These cell populations are called\\n"renewing" cell populations (141). Examples of 11 cell renewing\\nsystems" are epidermis and derivatives, gastrointestinal\\nepithelia, testis and blood-forming tissues. The size\\nand the functional capacity of such a cell population is\\ndependent on the precise bqlance between cell production\\nand cell loss, while some flexibility is needed to meet\\nwith possible perturbations of the system.
Author: R. P. C. Rijke
Language: English
Subfield: Gastroenterology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2111676527