Work

Spermatogonial stem cell regulation and spermatogenesis

Year: 2010

Type: review

Abstract: This article will provide an updated review of spermatogonial stem cells and their role in maintaining the spermatogenic lineage. Experimental tools used to study spermatogonial stem cells (SSCs) will be described, along with research using these tools to enhance our understanding of stem cell biology and spermatogenesis. Increased knowledge about the biology of SSCs improves our capacity to manipulate these cells for practical application. The chapter concludes with a discussion of future directions for fundamental investigation and practical applications of SSCs.

Source: Philosophical Transactions of the Royal Society B Biological Sciences

DOI: 10.1098/rstb.2010.0026

Authors: Bart T. Phillips, Kathrin Gassei, Kyle E. Orwig

Institutions: University of Pittsburgh, Magee-Womens Research Institute

Language: English

Topic: Sperm and Testicular Function

Subfield: Reproductive Medicine

Field: Medicine

Domain: Health Sciences

Open Access status: hybrid

Funders: Magee-Womens Research Institute, National Institutes of Health, Eunice Kennedy Shriver National Institute of Child Health and Human Development

Awards: Physiology and Pathophysiology of the Primate Gonad, G4744263134, CENTER FOR RESEARCH IN REPRODUCTIVE PHYSIOLOGY, Characterization of male germline stem cells in a rhesus model of infertility