The Untapped Potential of Genetically Engineered Mouse Models in Chemoprevention Research: Opportunities and Challenges
Year: 2008
Type: article
Abstract: The past decade has witnessed the unveiling of a powerful new generation of genetically engineered mouse (GEM) models of human cancer, which are proving to be highly effective for elucidating cancer mechanisms and interrogating novel experimental therapeutics. This new generation of GEM models are well suited for chemoprevention research, particularly for investigating progressive stages of carcinogenesis, identifying biomarkers for early detection and intervention, and preclinical assessment of novel agents or combinations of agents. Here we discuss opportunities and challenges for the application of GEM models in prevention research, as well as strategies to maximize their relevance for human cancer.
Source: Cancer Prevention Research
Institutions: University of North Carolina at Chapel Hill, National Institutes of Health, University of Arizona, Baylor College of Medicine, Cornell University, National Cancer Institute, Sidney Kimmel Comprehensive Cancer Center, Weill Cornell Medicine, University of Arizona Cancer Center, Herbert Irving Comprehensive Cancer Center, UNC Lineberger Comprehensive Cancer Center, Columbia University
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Awards: Modeling heterogeneity for safe cancer prevention and detection, MOLECULAR-NUTRIENT INTERACTIONS IN INTESTINAL CANCER, Prevention of Estrogen Receptor-negative Breast Cancer, G1420499056, Transgenic Models for Prostate and Breast Cancer, Elucidation of cancer pathways and druggable targets using mouse models., Prevention of APC-Dependent Intestinal Carcinogenesis, G4119534169, In Vitro and In Vivo screening of chemopreventive agents, G5850682332, G726073353, G7345991677, Molecular mechanisms of prostate cancer initiation, G837969362
OpenAlex ID: W2111878573