Year: 2008
Type: article
Study design: Observational Study
Abstract: As part of the Indianapolis-Ibadan dementia project, cognitive decline was monitored over 12 years. 1703 community-dwelling African Americans 65 yrs and over who were neither demented nor cognitively impaired at baseline. A total of 4 follow up evaluations were conducted after baseline. Only subjects who had a follow up evaluation were included in this analysis. Cognitive decline was evaluated using the CSI”D”, an instrument designed for use in literate and non-literate populations. It was constructed to measure ICD and DSM criteria for dementia. The cognitive portion contains a total of 56 items, measuring memory (28 items), semantic memory (language, 12 items) and executive function (16 items). During the 12 years of follow-up, 165 subjects developed incident dementia, 160 developed incident CIND, and 1378 remained not cognitively impaired. As might be anticipated subjects who developed incident demented showed the greatest cognitive decline compared to that of the non-cognitively impaired subjects with the CIND subjects occupying an intermediate position. Significant cognitive decline occurred over the 12 year period for the not cognitively impaired subjects even after excluding the incident dementia and CIND subjects and occurred in all 3 cognitive domains (memory, and executive p-values <0.0001; semantic p-value 0.0130). Increasing age was also significantly associated with cognitive decline for all domains. (p<0.0001). Significant cognitive decline was observed in all subjects in this large cohort of community-dwelling African Americans regardless of outcome status and across all cognitive domains. The semantic domain showed the least decline. The implications of these results will be discussed.
Source: Alzheimer s & Dementia
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2112090381