Work

Cocaine displaces [3H]WIN 35,428 binding to dopamine uptake sites in vivo more rapidly than mazindol or GBR 12909

Year: 1991

Type: article

Abstract: Previous studies have shown that [3H] WIN 35,428 binds preferentially to striatal cocaine receptors at the dopamine transporter after in vivo injection. In vivo binding competition studies were carried out to assess the relative rates of entry and occupancy of cocaine receptors by (-)-cocaine, mazindol and GBR 12909. After i.v. injection, (-)-cocaine occupied receptors relatively more rapidly than GBR 12,909 while mazindol was the slowest.

Source: European Journal of Pharmacology

DOI: 10.1016/0014-2999(91)90622-w

Authors: Sakire Pöḡün, Ursula Scheffel, Michael J. Kuhar

Institutions: Johns Hopkins University, Johns Hopkins Medicine, Johns Hopkins Hospital, National Institute on Drug Abuse

Language: English

Topic: Neurotransmitter Receptor Influence on Behavior

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,230