Work

Development of Echinocandin Resistance in Clavispora lusitaniae during Caspofungin Treatment

Year: 2011

Type: article

Abstract: Clavispora lusitaniae is an opportunistic human pathogen responsible for 0.6 to 2% of candidemia. This species is intrinsically susceptible to echinocandins. Nevertheless, in this study, development of echinocandin resistance in C. lusitaniae isolates was observed during caspofungin treatment. This resistance resulted from missense mutation in the echinocandin target Fks1 gene.

Source: Journal of Clinical Microbiology

DOI: 10.1128/jcm.00325-11

Authors: Marie Desnos-Ollivier, Olivier Moquet, Taieb Chouaki, Anne-Marie Guérin, Françoise Dromer

Institutions: Centre National de la Recherche Scientifique, Institut Pasteur, Centre Hospitalier de Beauvais, Centre Hospitalier Universitaire Amiens-Picardie

Language: English

Topic: Antifungal resistance and susceptibility

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: Institut de Veille Sanitaire