Study on changes in bone metabolism in a cohort of HIV-infected pregnant women and their uninfected children
Year: 2006
Type: article
Study design: Observational Study
Abstract: Osteopenia and osteoporosis are frequent in HIV-infected patients, \nbecause of disease itself and therapy. This study evaluated \nthe incidence of bone disorders in 18 infected pregnant \nwomen treated with antiretroviral drugs and in their uninfected \nchildren. \nBiochemical markers of bone metabolism were obtained every \nthree months in pregnant women and at 1, 6 and 12 month of \nage in children. Serum levels of calcium, inorganic phosphate, \nbone specific alkaline phosphatase were collected; moreover \nserum levels of osteocalcin and urinary CTX concentrations \nwere evaluated as bone synthesis and bone resorption index \nrespectively. Ultrasonographic bone densitometry was performed \nin women once in pregnancy and in children at 1, 6, 12 \nmonths of age. In order to critically analyze these data, a normal \nline was generated from data obtained from a cohort of 80 \nitalian children aged 0-12 months: this is the first study ever \nperformed on newborns and infants, in the aim to identify the \nnormal values of reference in this cluster of age. \nLower bone density values, compared with control subjects, \nwere detected in 7/18 women (38.8%): osteopenia was found \nin 3 women and osteoporosis in 4. Normal serum levels of osteocalcin \nwere detected in osteopenic patients while the \nserum concentrations were low (< 2.5 ng/ml) all over pregnancy \nin the four cases of osteoporosis. High CTX urinary concentration \nwas observed in 3 cases of osteoporosis. \nIn just 2 children (born to women who had started an antiretroviral \ntherapy with PIs before conception and have been \ntreated for more than 30 months) low bone density was diagnosed \nby ultrasonographic densitometry at the first month, \nbut it was found normal both at 6 and 12 months of age. Only \nin these two cases high CTX urinary concentration was observed \nat the first month, and was found normal at the following \nevaluations.
Institutions: Policlinico San Matteo Fondazione, University of Pavia
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2112240895