Work

Molecular Targeting of Neural Cancer Stem Cells: TTAGGG, You're It!

Year: 2011

Type: article

Abstract: Telomerase is an important mechanism by which cancers escape replicative senescence. In neural tumors, cancer stem cells express telomerase, suggesting that this may explain their preferential tumorigenesis. Oligonucleotide telomerase targeting selectively disrupts cancer stem cell growth through the induction of differentiation, adding to the armamentarium of anticancer stem cell therapies.

Source: Clinical Cancer Research

DOI: 10.1158/1078-0432.ccr-10-2686

Authors: Anita B. Hjelmeland, Jeremy N. Rich

Institutions: Cleveland Clinic, Case Comprehensive Cancer Center

Language: English

Topic: Telomeres, Telomerase, and Senescence

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Cancer Institute, National Institute of Neurological Disorders and Stroke