Work

Evidence for Packaging of rep-cap Sequences into Adeno-Associated Virus (AAV) Type 2 Capsids in the Absence of Inverted Terminal Repeats: a Model for Generation of rep -Positive AAV Particles

Year: 2002

Type: article

Abstract: We previously reported that a 350-bp region of the adeno-associated virus (AAV) type 2 rep gene contains a cis-acting element responsible for the Rep-dependent replication of a transiently transfected rep-cap plasmid. In this study, we further report that replicated rep-cap sequences can be packaged into AAV capsids in the absence of the inverted terminal repeats.

Source: Journal of Virology

DOI: 10.1128/jvi.77.1.776-781.2003

Authors: Pascale Nony, Gilliane Chadeuf, Jacques Tessier, Philippe Moullier, Anna Salvetti

Institution: Inserm

Language: English

Topic: Virus-based gene therapy research

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2112382843

FWCI: 0.744

Cites: 16

Cited by: 52

Related to: 10