Work

Iron(II)‐Catalyzed Trifluoromethylation of Potassium Vinyltrifluoroborates

Year: 2012

Type: article

Abstract: Exchanging BF3 by CF3: The title reaction proceeds under exceedingly mild reaction conditions and provides 2-arylvinyl- and 2-heteroarylvinyl-substituted substrates with E/Z selectivities of more than 95:5. Experimental observations suggest that the reaction does not proceed through a transmetalation of the RBF3K species to the iron catalyst.

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.201108267

Authors: Andrew T. Parsons, Todd D. Senecal, Stephen L. Buchwald

Institution: Massachusetts Institute of Technology

Language: English

Topic: Fluorine in Organic Chemistry

Subfield: Pharmaceutical Science

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

Open Access status: green

Funders: National Institutes of Health, U.S. Public Health Service, National Institute of General Medical Sciences, National Center for Research Resources