Work

9: Delta1: A Notch Up on Cord Blood Transplantation?

Year: 2007

Type: article

Abstract: Current evidence indicates a role for Notch signaling in regulating cell-fate decisions of hematopoietic precursors. Earlier work performed in our lab demonstrated enhanced self-renewal of repopulating cells due to retrovirus-mediated expression of a constitutively active form of Notch1. Subsequent studies demonstrated that activation of endogenous Notch receptors by exogenously presented Notch ligand was able to expand precursor cell numbers from human and murine non-mutant stem cells, including those with short-term and, in the case of human cells, possibly long-term repopulating ability.

Source: Transplantation and Cellular Therapy

DOI: 10.1016/j.bbmt.2007.08.017

Author: Colleen Delaney

Institution: Fred Hutch Cancer Center

Language: English

Topic: Hematopoietic Stem Cell Transplantation

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,650