Work

The key role of vitamin A in spermatogenesis

Year: 2010

Type: review

Abstract: Spermatogenesis in adult mammals is highly organized, with the goal being continual sperm production. Vertebrate testes are arranged into recurring cellular associations that vary with time and distance along the tubule. These changes over time and distance are designated the cycle of the seminiferous epithelium and the spermatogenic wave, respectively. In this Review, we briefly outline the roles that follicle-stimulating hormone (FSH) and testosterone play in regulating spermatogenesis and describe our current understanding of how vitamin A regulates germ cell differentiation and how it may lead to the generation of both the cycle of the seminiferous epithelium and the spermatogenic wave.

Source: Journal of Clinical Investigation

DOI: 10.1172/jci41303

Authors: Cathryn A. Hogarth, Michael D. Griswold

Institution: Washington State University

Language: English

Topic: Sperm and Testicular Function

Subfield: Reproductive Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Washington State University, National Institutes of Health, U.S. Public Health Service, Eunice Kennedy Shriver National Institute of Child Health and Human Development