Work

Intraluminal fluorescence spectroscopy catheter with ultrasound guidance

Year: 2009

Type: article

Abstract: We demonstrate the feasibility of a time-resolved fluorescence spectroscopy (TRFS) technique for intraluminal investigation of arterial vessel composition under intravascular ultrasound (IVUS) guidance. A prototype 1.8-mm (5.4 Fr) catheter combining a side-viewing optical fiber (SVOF) and an IVUS catheter was constructed and tested with in vitro vessel phantoms. The prototype catheter can locate a fluorophore in the phantom vessel wall, steer the SVOF in place, perform blood flushing under flow conditions, and acquire high-quality TRFS data using 337-nm wavelength excitation. The catheter steering capability used for the coregistration of the IVUS image plane and the SVOF beam produce a guiding precision to an arterial phantom wall site location of 0.53+/-0.16 mm. This new intravascular multimodal catheter enables the potential for in vivo arterial plaque composition identification using TRFS.

Source: Journal of Biomedical Optics

DOI: 10.1117/1.3146813

Authors: Douglas N. Stephens, Jesung Park, Yang Sun, Thanassis Papaioannou, Laura Marcu

Institutions: University of California, Davis, Cedars-Sinai Medical Center

Language: English

Topic: Optical Imaging and Spectroscopy Techniques

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

Open Access status: bronze

Funders: Boston Scientific Corporation, National Institutes of Health, National Heart, Lung, and Blood Institute

Award: Rupture prone plaque diagnosis by IVUS-guided time-resolved spectroscopy