Work

Effects of Dexmedetomidine on Contractility, Relaxation, and Intracellular Calcium Transients of Isolated Ventricular Myocardium

Year: 1990

Type: article

Abstract: The effects of the highly selective alpha 2-adrenoceptor agonist dexmedetomidine on contractility, relaxation, and the intracellular Ca2+ transients of isolated ventricular myocardium were studied in isolated right ventricular papillary muscles obtained from reserpinized ferrets. Dexmedetomidine (10(-10)-10(-5) M) did not alter amplitude and time variables of isometric, isotonic and zero-load-clamped twitches, except for a slight increase in maximal isotonic relaxation rate at 10(-5) M. Dexmedetomidine (10(-8)-10(-5) M) caused no changes in the intracellular Ca2+ transient detected with aequorin. These results suggest that dexmedetomidine has no intrinsic myocardial contractile effects.

Source: Anesthesiology

DOI: 10.1097/00000542-199011000-00020

Author: Philippe R. Housmans

Institution: Mayo Clinic

Language: English

Topic: Anesthesia and Sedative Agents

Subfield: Anesthesiology and Pain Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: National Institute of General Medical Sciences