Work

The major cysteine proteinase (cruzipain) from Trypanosoma cruzi is antigenic in human infections

Year: 1991

Type: article

Abstract: Antibodies against the major cysteine proteinase (cruzipain) from Trypanosoma cruzi were detected in human sera obtained from patients with chronic Chagas' disease. Not only the intact 60-kDa enzyme but also its 25-kDa self-proteolysis fragment are antigenic in vivo. Although T. cruzi antigens 13 and 36 also reacted with the apparently monospecific antiproteinase serum, the antigenicity of cruzipain to human patients is genuine, since its reactivity was not modified by the adsorption of human sera with the recombinant proteins 13 and 36.

Source: Infection and Immunity

DOI: 10.1128/iai.59.11.4275-4277.1991

Authors: J Martinez, O Campetella, A C Frasch, J J Cazzulo

Institutions: Consejo Nacional de Investigaciones Científicas y Técnicas, Universidad de Buenos Aires

Language: English

Topic: Trypanosoma species research and implications

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2113110175

FWCI: 3.14

Cites: 15

Cited by: 69

Related to: 10