Work

General Catalysts for the Suzuki–Miyaura and Sonogashira Coupling Reactions of Aryl Chlorides and for the Coupling of Challenging Substrate Combinations in Water

Year: 2005

Type: article

Abstract: Amphiphilic phosphine ligands (see structures; Cy=cyclohexyl) were prepared and utilized in palladium-catalyzed Suzuki–Miyaura and Sonogashira coupling reactions in water or water/organic biphasic solvents, providing excellent yields of functionalized biaryls and aryl alkynes, respectively.

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.200502017

Authors: Kevin W. Anderson, Stephen L. Buchwald

Institution: Massachusetts Institute of Technology

Language: English

Topic: Catalytic Cross-Coupling Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

Funders: National Institutes of Health, National Cancer Institute, National Institute of General Medical Sciences