Work

Particle/Fluid Interface Replication as a Means of Producing Topographically Patterned Polydimethylsiloxane Surfaces for Deposition of Lipid Bilayers

Year: 2010

Type: article

Abstract: A simple method to produce topographically patterned substrates from polydimethylsiloxane (PDMS) is presented. Surfaces with positively or negatively curved features, a combination of positively and negatively curved features or geometrically complex biomimetic features are fabricated. High-quality lipid bilayers that conform to the topography of the substrates can be prepared, a characteristic useful for biophysical studies.

Source: Advanced Materials

DOI: 10.1002/adma.200903625

Authors: Anand Bala Subramaniam, Sigolene Lecuyer, Kumaran S. Ramamurthi, Richard Losick, Howard A. Stone

Institutions: Harvard University, Princeton University, National Institutes of Health, National Cancer Institute

Language: English

Topic: Nanofabrication and Lithography Techniques

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

Open Access status: green

Funders: Materials Research Science and Engineering Center, Harvard University, National Institute of General Medical Sciences

Award: Role of RNA polymerase in bacterial differentiation