Reservoir Targeted Vaccine Against Borrelia burgdorferi: A New Strategy to Prevent Lyme Disease Transmission
Year: 2014
Type: article
Abstract: A high prevalence of infection with Borrelia burgdorferi in ixodid ticks is correlated with a high incidence of Lyme disease. The transmission of B. burgdorferi to humans can be disrupted by targeting 2 key elements in its enzootic cycle: the reservoir host and the tick vector. In a prospective 5-year field trial, we show that oral vaccination of wild white-footed mice resulted in outer surface protein A-specific seropositivity that led to reductions of 23% and 76% in the nymphal infection prevalence in a cumulative, time-dependent manner (2 and 5 years, respectively), whereas the proportion of infected ticks recovered from control plots varied randomly over time. Significant decreases in tick infection prevalence were observed within 3 years of vaccine deployment. Implementation of such a long-term public health measure could substantially reduce the risk of human exposure to Lyme disease.
Authors: L. M. Richer, D. Brisson, R. Melo, R. S. Ostfeld, N. Zeidner, M. Gomes-Solecki
Language: English
Subfield: Parasitology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: bronze
Awards: G2483872328, G3607312383, G3726377864, LTREB: Acorn pulses and the dynamics of rodents, ticks, and Lyme-disease risk in oak forests, G6209511441, RESERVOIR TARGETED VACCINE FO RTHE CONTROL OF LYME BORRELIOSIS, G6914964474, Causes and consequences of ospC variation in Borrelia burgdorferi to Lyme disease
OpenAlex ID: W2113238521