Studies of small DNA viruses found in various adenovirus preparations: physical, biological, and immunological characteristics.
Year: 1966
Type: article
Abstract: Electron microscopic studies of adenovirus preparations have revealed the presence of small "virus-like" particles approximately 22 m,4 in diameter in a number of human and simian adenovirus types.1-5Some workers have interpreted these particles as being adenovirus subunits,4-6 while others1-3 have indicated that they represent a contaminating virus.Our early studies1 suggested that the 22-mA particles were viruses which replicated poorly, if at all, in human cells in the absence of adenovirus replication.Atchison et al.2 also presented evidence that the small particles were infectious, that they were defective, and that they were immunologi- cally distinct from any known adenovirus antigen.They tentatively referred to this virus as adeno-associated virus (AAV) and we shall continue to use this name.The purpose of the present report is to describe some of the physical, biological, and immunological characteristics of the small particles found in various adeno- virus preparations with further evidence that they are defective viruses and not adenovirus subunits.
Authors: M D Hoggan, N R Blacklow, W P Rowe
Institutions: National Institutes of Health, National Cancer Institute
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2113259183