Work

Transforming growth factor-β receptor III downregulation in prostate cancer: is inhibin B a tumor suppressor in prostate?

Year: 2007

Type: article

Abstract: The transforming growth factor-beta (TGF-beta) pathway plays dual roles in cancer, inhibiting epithelial cell growth under normal physiologic conditions, but promoting invasion and metastasis once growth inhibitory responses are lost. Two recent papers show that TGF-beta receptor III is the most common TGF-beta pathway component downregulated in prostate cancer. Here, we discuss the implications of these findings and what it may mean about the biology of this disease.

Source: Journal of Molecular Endocrinology

DOI: 10.1677/jme-07-0084

Authors: Nima Sharifi, Robert J Lechleider, William L Farrar

Institutions: Frederick National Laboratory for Cancer Research, National Cancer Institute, Center for Cancer Research, National Institutes of Health

Language: English

Topic: TGF-β signaling in diseases

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Institutes of Health, National Cancer Institute