Work

DNA and RNA in Anhydrous Media: Duplex, Triplex, and G‐Quadruplex Secondary Structures in a Deep Eutectic Solvent

Year: 2010

Type: article

Abstract: Hold the water! Deep-eutectic solvents (DESs) are nonvolatile media suitable for a wide range of chemical reactions. The discovery that nucleic acids can form duplex, triplex, and G-quadruplex structures (which in some cases differ from those adopted in aqueous media) in a water-free DES (see picture) opens the enticing possibility that catalytic nucleic acids and enzyme–nucleic acid complexes could also be used in these solvents.

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.201001561

Authors: Irena Mamajanov, Aaron E. Engelhart, Heather D. Bean, Nicholas V. Hud

Institution: Georgia Institute of Technology

Language: English

Topic: DNA and Nucleic Acid Chemistry

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

Funders: National Science Foundation, Division of Chemistry

Award: CBCI: The Origins Project