Year: 2014
Type: review
Abstract: IgA nephropathy (IgAN) represents the leading cause of kidney failure among East Asian populations and the most frequent form of primary glomerulonephritis among Europeans. Patients with IgAN develop characteristic IgA1-containing immune complexes that deposit in the glomerular mesangium, producing progressive kidney injury. Recent studies define IgAN as an autoimmune trait of complex architecture with a strong genetic determination. This Review summarizes new insights into the role of the O-glycosylation pathway, anti-glycan immune response, mucosal immunity, antigen processing and presentation, and the alternative complement pathway in the pathogenesis of IgAN.
DOI: 10.1172/jci74475
Authors: Krzysztof Kiryluk, Jan Novak
Institutions: Columbia University, University of Alabama at Birmingham
Language: English
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Awards: Molecular Basis of Pathogenicity of IgA1-containing Immune Complexes, Analytical tools for the analysis of clustered O-glycans in clinical samples, G1975117797, Elucidating IgA nephropathy through Genetic Studies of IgA1 Glycosylation, G4464941625, G4598953102, G6287158219, Quantitative Genetics of Defective IgA1 Glycosylation in IgA Nephropathy, G9000019921, G9000064520, Molecular Basis of Pathogenicity of IgA1-containing Immune Complexes, G944034983
OpenAlex ID: W2113470371