Work

Transcriptional regulatory circuits controlling mitochondrial biogenesis and function

Year: 2004

Type: preprint

Abstract: We are witnessing a period of renewed interest in the biology of the mitochondrion. The mitochondrion serves a critical function in the maintenance of cellular energy stores, thermogenesis, and apoptosis. Moreover, alterations in mitochondrial function contribute to several inherited and acquired human diseases and the aging process. This review summarizes our understanding of the transcriptional regulatory mechanisms involved in the biogenesis and energy metabolic function of mitochondria in higher organisms.

Source: Genes & Development

DOI: 10.1101/gad.1177604

Authors: Daniel P. Kelly, Richard C. Scarpulla

Institution: Washington University in St. Louis

Language: English

Topic: Mitochondrial Function and Pathology

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze