Work

T-Cell Infiltration Correlates with CXCL10 Expression in Ganglia of Cynomolgus Macaques with Reactivated Simian Varicella Virus

Year: 2012

Type: article

Abstract: Ganglia of monkeys with reactivated simian varicella virus (SVV) contained more CD8 than CD4 T cells around neurons. The abundance of CD8 T cells was greater less than 2 months after reactivation than that at later times and correlated with that of CXCL10 RNA but not with those of SVV protein or open reading frame 61 (ORF61) antisense RNA. CXCL10 RNA colocalized with T-cell clusters. After SVV reactivation, transient T-cell infiltration, possibly mediated by CXCL10, parallels varicella zoster virus (VZV) reactivation in humans.

Source: Journal of Virology

DOI: 10.1128/jvi.03181-12

Authors: Werner J. D. Ouwendijk, Allison Abendroth, Vicki Traina-Dorge, Sarah Getu, Megan Steain, Mary Wellish, Arno C. Andeweg, Albert D. M. E. Osterhaus, Don Gilden, Georges M. G. M. Verjans, Ravi Mahalingam

Institutions: Erasmus MC, Westmead Institute for Medical Research, Tulane University, University of Colorado Anschutz

Language: English

Topic: Herpesvirus Infections and Treatments

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute on Aging, National Center for Research Resources

Awards: G1015710804, G1040925181, G1309856127, G1309951042, G1626957303, G1671339645, G2019221917, G2616847872, G2692219546, G3757142140, G4495922382, G5075530300, G5535863426, A major contributor of serious multisystem disease in the elderly: varicella zoster virus-induced inflammation, G7136933086, G8134191220, BLDG D RENOV-ANIMAL RESOURCES IMPROVEMENTS, G8349630629, G8570581560

OpenAlex ID: W2113574445

FWCI: 3.013

Cites: 16

Cited by: 31

Related to: 10