The Association Between Maternal Glucose Concentration and Child BMI at Age 3 Years
Year: 2011
Type: article
Study design: Observational Study
Abstract: OBJECTIVE: The objective of the study was to determine the association between child BMI at age 3 years and maternal glucose concentration among women without pre-existing diabetes or a gestational diabetes mellitus (GDM) diagnosis. RESEARCH DESIGN AND METHODS: Data are from the Pregnancy Infection and Nutrition and Postpartum studies and include 263 mother-child pairs. Measured weights and heights at 3 years were used to calculate age- and sex-specific BMI z scores and percentiles. Multivariable linear regression models were used to examine associations of continuous BMI z scores with maternal glucose concentration. Modified Poisson regression estimated risk ratios of child overweight/obesity (BMI ≥ 85th percentile). RESULTS: The mean (SD) maternal glucose concentration and prepregnancy BMI were 103.8 (23.7) mg/dL and 24.3 (5.9) kg/m(2), respectively. At 3 years, the mean (SD) child BMI z score was 0.29 (0.99), 20.9% were overweight/obese and 5.3% were obese. In the adjusted model, when compared with glucose concentration <100 mg/dL, a concentration ≥ 130 mg/dL was associated with significantly higher child BMI z score at 3 years (estimated z score difference of 0.39 [95% CI: 0.03-0.75]). With the use of the same reference category, a concentration ≥ 130 mg/dL was associated with an approximate twofold greater risk of child overweight/obesity (adjusted risk ratio 2.34 [95% CI: 1.25-4.38]). CONCLUSIONS: Fetal exposure to high maternal glucose concentration in the absence of pre-existing diabetes or GDM may contribute to the development of overweight/obesity in the offspring, independent of maternal prepregnancy BMI.
Source: Diabetes Care
DOI: 10.2337/dc10-1766
Language: English
Subfield: Obstetrics and Gynecology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Funders: Brown University, National Institutes of Health, University of North Carolina at Chapel Hill, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Environmental Health Sciences, National Institute of Child Health and Human Development, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Carolina Population Center, University of North Carolina at Chapel Hill
Awards: G1017297203, Carolina Population Center, G1789099407, EPIDEMIOLOGY OF EXERTION, STRESS, AND PRETERM DELIVERY, G3359341346, G491315329, Placental Vascular Compromise and Preterm Delivery, G633297803, G738783015, Pregnancy Related Weight Gain: A Link to Obesity, UNC Center for Environmental Health and Susceptibility, Nutrition Obesity Research Center (NORC)
OpenAlex ID: W2113589746