Work

HIV DNA Vaccine: Stepwise Improvements Make a Difference

Year: 2014

Type: review

Abstract: Inefficient DNA delivery methods and low expression of plasmid DNA have been major obstacles for the use of plasmid DNA as vaccine for HIV/AIDS. This review describes successful efforts to improve DNA vaccine methodology over the past ~30 years. DNA vaccination, either alone or in combination with other methods, has the potential to be a rapid, safe, and effective vaccine platform against AIDS. Recent clinical trials suggest the feasibility of its translation to the clinic.

Source: Vaccines

DOI: 10.3390/vaccines2020354

Authors: Barbara Felber, Antonio Valentin, Margherita Rosati, Cristina Bergamaschi, George Pavlakis

Institutions: Frederick National Laboratory for Cancer Research, National Cancer Institute, Center for Cancer Research

Language: English

Topic: HIV Research and Treatment

Subfield: Virology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,258