Work

Vicious circle: systemic autoreactivity in Ro52/TRIM21-deficient mice

Year: 2009

Type: article

Abstract: Dysregulated innate responses, particularly excessive activation of interferon (IFN) pathways, have been implicated in the development of autoimmune pathologies. Autoreactivity frequently targets IFN-inducible genes such as the Ro autoantigens, which ubiquitinate and inhibit interferon regulatory factors (IRFs). A new study validates the role of these common autoantigens in preventing autoimmunity. The findings reveal that injury-induced systemic autoimmune disease is exacerbated in the absence of Ro52/Trim21 and is driven by the IL-23-Th17 pathway.

Source: The Journal of Experimental Medicine

DOI: 10.1084/jem.20091507

Authors: Silvia Bolland, Adolfo Garcia-Sastre

Institutions: National Institutes of Health, National Institute of Allergy and Infectious Diseases, Icahn School of Medicine at Mount Sinai

Language: English

Topic: Systemic Lupus Erythematosus Research

Subfield: Rheumatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute of Allergy and Infectious Diseases