Work

Redox-responsive self-assembled chain-shattering polymeric therapeutics

Year: 2015

Type: article

Abstract: We report the design and development of redox-responsive chain-shattering polymeric therapeutics (CSPTs). CSPTs were synthesized by condensation polymerization and further modified with poly(ethylene glycol) (PEG) via "Click" reaction. Size-controlled CSPT nanoparticles (NPs) were formed through nanoprecipitation with high drug loading (up to 18%); the particle size increased in a concentration dependent manner. Drug release from particles was well controlled over 48 h upon redox triggering. The anticancer efficacy of the CSPT NPs was validated both in vitro and in vivo.

Source: Biomaterials Science

DOI: 10.1039/c4bm00452c

Authors: Kaimin Cai, Jonathan Yen, Qian Yin, Yang Liu, Ziyuan Song, Stéphane Lezmi, Yanfeng Zhang, Xujuan Yang, William G. Helferich, Jianjun Cheng

Institution: University of Illinois Urbana-Champaign

Language: English

Topic: Nanoparticle-Based Drug Delivery

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Science Foundation, U.S. Department of Health and Human Services, National Institutes of Health, University of Illinois at Urbana-Champaign, National Cancer Institute, Division of Materials Research

Awards: G1804017744, G2364327924, G3500118554, Training the Next Generation of Researchers in Cancer Nanotechnology at the NCI M, Developing Clinically Applicable, Cancer-Targeting Polymeric Nanoconjugates, G4778635926, Camptothecin-Containing Nanoparticles: Control Over Particle Size, Biodistributio

OpenAlex ID: W2113737449

FWCI: 2.408

Cites: 53

Cited by: 38

Related to: 10