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Targeted Heritable Mutation and Gene Conversion by Cas9-CRISPR in Caenorhabditis elegans

Year: 2013
Type: article
Abstract: We have achieved targeted heritable genome modification in Caenorhabditis elegans by injecting mRNA of the nuclease Cas9 and Cas9 guide RNAs. This system rapidly creates precise genomic changes, including knockouts and transgene-instructed gene conversion.
Source: Genetics
DOI: 10.1534/genetics.113.155754
Language: English
Open Access status: bronze
Funders: National Science Foundation, Friedrich Miescher Institute for Biomedical Research, European Commission, Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung, National Institutes of Health, FP7 Ideas: European Research Council
Awards: Mineral microparticle-organic macromolecule-heavy metal interactions in natural waters: speciation at the nanoscale with analytical electron microscopies, G2111793168, G2170545789, Mechanisms and Developmental Functions of MicroRNA Turnover: The Exoribonuclease XRN2, Mechanisms of microRNA biogenesis and turnover, Caenorhabditis Genetics Center
OpenAlex ID: W2113742465
FWCI: 7.148
Cites: 36
Cited by: 95
Related to: 10