Work

PIP 2 Is a Necessary Cofactor for Ion Channel Function: How and Why?

Year: 2008

Type: review

Abstract: Phosphatidylinositol 4,5-bisphosphate (PIP2) is a minority phospholipid of the inner leaflet of plasma membranes. Many plasma membrane ion channels and ion transporters require PIP2 to function and can be turned off by signaling pathways that deplete PIP2. This review discusses the dependence of ion channels on phosphoinositides and considers possible mechanisms by which PIP2 and analogues regulate ion channel activity.

Source: Annual Review of Biophysics

DOI: 10.1146/annurev.biophys.37.032807.125859

Authors: Byung-Chang Suh, Bertil Hille

Institution: University of Washington

Language: English

Topic: Ion channel regulation and function

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: National Institutes of Health, National Institute of General Medical Sciences, National Institute of Neurological Disorders and Stroke

Awards: Molecular Properties of Ionic Permeability in Nerve, G83771071, Electric studies of excitation, secretion & contraction, Molecular Properties of Ionic Permeability in Nerve