Work

New Frontiers for the NFIL3 bZIP Transcription Factor in Cancer, Metabolism and Beyond

Year: 2014

Type: article

Abstract: The bZIP transcription factor NFIL3 (Nuclear factor Interleukin 3 regulated, also known as E4 binding protein 4, E4BP4) regulates diverse biological processes from circadian rhythm to cellular viability. Recently, a host of novel roles have been identified for NFIL3 in immunological signal transduction, cancer, aging and metabolism. Elucidating the signaling pathways that are impacted by NFIL3 and the regulatory mechanisms that it targets, inhibits or activates will be critical for developing a clearer picture of its physiological roles in disease and normal processes. This review will discuss the recent advances and emerging issues regarding NFIL3-mediated transcriptional regulation of CEBPβ and FOXO1 activated genes and signal transduction.

Source: Discoveries

DOI: 10.15190/d.2014.7

Authors: Megan Keniry, Robert K. Dearth, Michael Persans, Ramon Parsons

Institution: Icahn School of Medicine at Mount Sinai

Language: English

Topic: FOXO transcription factor regulation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funder: National Cancer Institute