Work

Lipid-based patterning of the immunological synapse

Year: 2014

Type: review

Abstract: The immunological synapse controls T-lymphocyte function by polarizing effector responses towards the antigen-presenting cell. In this review, I discuss the molecular pathways required for synapse assembly, focusing on the central roles played by lipid second-messenger signalling.

Source: Biochemical Society Transactions

DOI: 10.1042/bst20140191

Author: Morgan Huse

Institution: Memorial Sloan Kettering Cancer Center

Language: English

Topic: T-cell and B-cell Immunology

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

Open Access status: green

Funders: National Cancer Institute, National Institute of Allergy and Infectious Diseases

Awards: Cancer Center Support Grant, Mechanoregulation of cytotoxic lymphocyte function