Work

Suppression of p53-dependent senescence by the JNK signal transduction pathway

Year: 2007

Type: article

Abstract: The JNK signaling pathway is implicated in the regulation of the AP1 transcription factor and cell proliferation. Here, we examine the role of JNK by using conditional and chemical genetic alleles of the ubiquitously expressed murine genes that encode the isoforms JNK1 and JNK2. Our analysis demonstrates that JNK is not essential for proliferation. However, JNK is required for expression of the cJun and JunD components of the AP1 transcription factor, and JNK-deficient cells exhibit early p53-dependent senescence. These data demonstrate that JNK can act as a negative regulator of the p53 tumor suppressor.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.0707782104

Authors: Madhumita Das, Feng Jiang, Hayla K. Sluss, Chao Zhang, Kevan M. Shokat, Richard A. Flavell, Roger J. Davis

Institutions: Howard Hughes Medical Institute, University of Massachusetts Chan Medical School, University of California, San Francisco, Yale University

Language: English

Topic: Telomeres, Telomerase, and Senescence

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2114125896

FWCI: 5.535

Cites: 27

Cited by: 143

Related to: 10